Base‐Assisted Electrografting of Aromatic Amines

Nitrosamines and Aromatic Amines

A new method for the simultaneous determination of hemoglobin adducts from aromatic amines and tobacco-specific nitrosamines (TSNA) is described. After mild base-catalysed hydrolysis releasing aromatic amines and the TSNA adduct 4-hydroxy-1-(3-pyridyl)-1butanone (HPB), the extraction, cleanup, and concentration are performed by a one-step procedure using C 1 8 cartridges. Determination in the p...

The Biochemistry of Aromatic Amines

1. 2-Naphthylhydroxylamine and 2-nitrosonaphthalene were present in urine of dogs but not of guinea pigs, hamsters, rabbits or rats dosed with 2-naphthylamine. N-Acetyl-2-naphthylhydroxylamine and its O-sulphonic acid and O-glucosiduronic acid were not detected in the urine of any of these species. 2. Bile from rats dosed with 2-naphthylamine contained (2-naphthylamine N-glucosid)uronic acid an...

Bacterial degradation of monocyclic aromatic amines

Aromatic amines are an important group of industrial chemicals, which are widely used for manufacturing of dyes, pesticides, drugs, pigments, and other industrial products. These compounds have been considered highly toxic to human beings due to their carcinogenic nature. Three groups of aromatic amines have been recognized: monocyclic, polycyclic, and heterocyclic aromatic amines. Bacterial de...

Metabolism of aromatic amino acids and amines.

Interaction of Aromatic Amines with Rat Liver

A number of stable protein adducts formed by the interaction of trace amounts of a metabolite or metabolites of the carcinogenic aromatic amide, N-2-fluorenylacetamide-9J4C, with the nuclear proteins of rat liver have been isolated and purified to constant specific radioactivity with the use of gel titration on Sephadex G-25 and of ion exchange chromatography on carboxymethyl cellulose. Certain...